Chemotherapy of Malaria and Resistance to Antimalarials
İÇİNDEKİLERCONTENTS Introduction 1. Review of the current use of antimalarials in clinical practice and in malaria control and eradication programmes.................. 1.1 Treatment of acute falciparum malaria.............. 1.2 Presumptive treatment...................... 1.3 Mass drug administration.................... 1.4 Radical treatment........................ 2..Review of clinical studies and field trials of older antimalarials....... 2.1 Quinine 2.2 Mepacrihe 2.3 4-Aminoquinolines........................ 2.4 8-Aminoquinolines.......................... 2.5 Dihydrofolate reductase inhibitors................. 2.6 Sulfonamides and sulfones 2.7 Tetracyclines.......................... 2.8 Drug associations........................ 3. Resistance of human malaria to drugs..... ........... 3.1 Spectrum of response of malaria to drugs ............ 3.2 Procedures for assessing drug response.............. 3.3 Geographical distribution of drug-resistant malaria......... 3.4 Measures to be taken in areas of established drug resistance 4. Recent progress in antimalarial drug research.............. 4.1 Basic research on mode of action of antimalarial drugs and drug resistance 4.2 Preliminary experimental data on new antimalarials........ 4.3 Results of clinical evaluation of new antimalarials......... 5. Future problems and prospects for antimalarial drugs.......... 5.1 Future importance of antimalarials and drug resistance....... 5.2 Support for research on chemotherapy of malaria......... 6. Conclusions and recommendations................... Annex 1. Structural formulae of antimalarial drugs............ Annex 2. International nonproprietary names of newer synthetic antimalarials and some synonyms and proprietary names........... Annex 3. Sample form for reporting individual results of field test for strain sensitivity to a standard dose of chloroquine in falciparum malaria . Annex 4. Procedures for screening potential antimalarial compounds.....  |
