Pharmacogenetics
İÇİNDEKİLERCONTENTS 1. Introduction............................. 2. General considerations......................... 3. Methods............................... 3.1 General remarks........................ 3.2 Pharmacological methods.................... 3.3 Biochemical genetics....................... 3.4 Human genetics methods..................... 4. Pharmacogenetic variants with mendelian inheritance........... 4.1 G6PD deficiency........................ 4.2 Acetyltransferase polymorphism.................. 4.3 Genetic variation of the intraocular pressure response to glucocorticoids 4.4 Methaemoglobin reductase deficiency............... 4.5 Cholinesterase variants...................... 4.6 Malignant hyperthermia..................... 4.7 Coumarin resistance....................... 4.8 Drug-sensitive haemoglobins................... 4.9 Phenytoin hydroxylation..................... 5. Multifactorial variability and polygenic inheritance............ 5.1 The paucity of pharmacogenetic polymorphisms........... 5.2 Practical relevance of considerations of variability.......... 5.3 Genetic methods of investigating multifactorial variability...... 5.4 Correlation between the rates of elimination of different drugs in the same individual......................... 5.5 The influence of miscellaneous factors on the variability of drug metabolism and pharmacological response................ 5.6 Practical applications...................... 5.7 A polymorphism involved in a polygenic system........... 5.8 Interethnic differences in polygenic systems of drug metabolism 6. Genetic disorders with altered drug sensitivity............... 6.1 Gout and HGPRT deficiency................... 6.2 Hepatic porphyrias....................... 6.3 Hyperbilirubinaemia....................... 6.4 Bleeding disorders........................ 6.5 Osteogenesis imperfecta..................... 6.6 Periodic paralysis........................ 6.7 Familial dysautonomia (Riley-Day syndrome)........... 6.8 Huntington's chorea....................... 7. States in which genetic factors may alter drug response.......... 7.1 Toxic effects produced by environmental agents........... 7.2 Pharmacogenetic effects of toxic substances ............ 7.3 Mutagenic effects of environmental contaminants.......... 7.4 Drugs of abuse and addiction syndromes.............. 7.5 Various neuropsychiatric conditions................ 7.6 Phenothiazine drugs....................... 8. Public health aspects of pharmacogenetics................ 9. Recommendations.......................... 10. Conclusions.............................  |
