Chemotherapy of Malaria
İÇİNDEKİLERCONTENTS Introduction............................... 1. Recent work on antimalarial drugs................... 1.1 Results of laboratory research and screening of new compounds . . . 1.2 Results of preliminary studies and field trials :.......... 2. Drugs for prevention and treatment of malaria........... 2.1 Available drugs and their application............... 2.2 Drug administration in eradication programmes .......... 2.3 Drug administration in pre-eradication programmes ........ 3. Resistance of human malaria parasites to drugs............. 3.1 Spectrum of response...................... 3.2 Geographical distribution of falciparum malaria resistant to 4-amino-quinolines............................ 3.3 New criteria of drug resistance and amended procedures for assessing response to treatment...................... 3.4 Measures to counter drug resistance in the field.......... 4. Future research on the chemotherapy of malaria............ 4.1 Sensitivity of malaria parasites to drugs.............. 4.2 Field studies and the development of new drugs.......... 4.3 Basic research in laboratory models................ 5. Conclusions and recommendations................... Annex 1. Structural formulae of antimalarial drugs............. Annex 2. International non-proprietary names of synthetic antimalarial drugs and some synonyms and proprietary names ........... Annex 3. Patterns of cross resistance and sensitivity in strains of various species of plasmodia with experimentally produced resistance....... Annex 4. Results of studies of some strains of P. falciparum from South-East Asia Annex 5.Response to chloroquine in strains of P. falciparum from South-East Asia Annex 6. Response to quinine in strains of P. falciparum from South-East Asia Annex 7. Response to chloroquine of some strains of blood induced P. falciparum infections from South America................. Annex 8. Response to various drugs of infections induced with strains of P. falciparum from South America .................. Annex 9. Individual results of field test for strain sensitivity to a standard dose of chloroquine in falciparum malaria.............. Annex 10. Summary of results of field test for strain sensitivity to a standard dose of chloroquine in falciparum malaria..............  |
