Scandinavian Journal of Work, Environment & Health

Book : Scandinavian Journal of Work, Environment & Health

Author : * --

Language : English

Episode : Health-Safety-Environment

Publishing Location : Danimarka

ISSN : 0355-3140

Skin : 22-3

Period : bimonthly

Published Date : 1996

Publisher : Finnish Institute of Occupational Health

Document Type : Periodical

Book No : 1387

INDEX

CONTENTS - Supplement 3,1996
Preface Abstract
5 Ozone and other photochemical oxidants in ambient and indoor air - properties, sources and concentrations
by J Sundell, A Zuber
5 Physical and chemical properties
5 Formation mechanisms of ozone and photochemical
oxidants
7 Occurrence of ozone in urban and rural areas
7 Annual and daily variations
8 Episodes with high concentrations of ozone
8 Ozone background level
9 Relationship between short- and long-term averages
9 Ozone indoors
10 Indoor-outdoor relationships
11 Personal exposure
11 Indirect effects of indoor ozone
12 Some techniques to determine the concentration of
ozone in ambient air
12 Wet-chemical techniques
12 Optical techniques
12 Ozone dosimeters
12 Current air quality guidelines and standards
12 World Health Organization
12 United Nations Economic Commission for Europe
13 United States air quality standards
13 European Union
13 Sweden
13 Summary and concluding remarks
13 References
15 Absorption and metabolic fate of ozone - the molecular basis of ozone-induced toxicity
by I A Cotgreave
15 Chemical relationships between ozone and reactive
oxygen metabolites
16 Absorption of ozone into the lung
17 Reactivity of ozone with biological molecules
17 General reactivity with organic molecules
17 Reaction with biological antioxidants
18 Reaction with lipids
19 Reaction with proteins
20 Reactions with nucleic acids
21 Ozone-induced alterations to macromolecule structure
and function and their influence on biochemical processes
21 Lipid-dependent processes
22 Protein-dependent processes
23 DNA-dependent processes
23 Summary and concluding remarks
24 References


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Ozone-induced toxicity in experimental animals and isolated cell systems
by IE Gustafsson, I Cotgreave
Effects on respiratory system morphology Affected cells and sites Effects on lung morphology in primates Effects on morphology in other species Comparison between ozone and oxygen toxicity Summary
Host defense mechanisms Mucociliary clearance Alveolar macrophages Immunologic mechanisms Interactions between infectious agents Effects on some cellular responses in vitro Summary
Sensitization to allergens
Effects on lung function
Breathing pattern, airway resistance and lung compliance Airway responsiveness Summary
Proinflammatory effects of ozone in animal models
Inflammatory process, friend or foe?
Ozone and pulmonary inflammation in animals Acute inflammatory responses to ozone Chronic inflammatory responses to ozone Summary
Summary and concluding remarks References Genotoxicity and carcinogenicity of ozone
by K Victorin
Genotoxic effects in vitro
Reactions with DNA and RNA Genotoxic effects on microorganisms, plants and insects Cell cultures
Cytogenetic effects
Effects on DNA
Cell transformation in vitro
Summary
Genotoxic effects in vivo Animal experiments Human exposure Summary
Tumor induction
Summary and concluding remarks
References
Controlled human studies of ozone exposure
by G Bylin
Lung function measurements
Forced expiratory volume and vital capacity

Airway resistance and lung volume Forced expiratory flow and the maximal expiratory flow-volume curve Breathing pattern and oxygen uptake
Lung function after single exposure Effects of ozone on the lung function of normal subjects
Reproducibility of ozone effects on lung
function
Age-dependency of ozone effects on
lung function
Effects of gender on ozone-involved
effects on lung function
Relationship between ozone dose and
lung function change
Relationship between ozone-induced
symptoms and lung function change
Effects of pharmacological agents on
ozone-induced changes in lung functior Lung function in subjects with airway or heart disease
Allergic rhinitis
Asthma
Chronic obstructive pulmonary disease
Ischemic heart disease Summary
Lung function after repeated exposures
Airway responsiveness
Airway responsiveness in normal subjects Airway responsiveness in asthmatic subjects Summary
Exercise performance
Inflammatory reactions in the airways Inflammatory reactions in the bronchi Inflammatory reactions in the upper airways
Host defense
Host defense against virus Airway epithelial permeability Mucosiliary clearance
Combination with other pollutants
Effects of ozone mixed with other pollutants Effects of sequential exposure to ozone and other pollutants
Effects of ozone in ambient air studied in mobile laboratories
Summary and concluding remarks References
Epidemiologic studies on ozone
by F Nyberg, G Pershagen
Symptoms and symptom exacerbation Symptoms in healthy subjects
Studies on Los Angeles studen nurse • The Tuscon studies Other American studies





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European studies
Summer camp studies
Exercise studies
Symptoms exacerbation in subjects with respiratory disease
Daily life studies on groups of
asthmatics and respiratory disease
patients
Summer camp studies Summary
Lung function in adults Daily life studies Summer camp studies Exercise studies Summary
Lung function in children Daily life studies Summer camp studies Exercise studies Summary
Hospital admissions and outpatient visits Hospital admissions
Studies in the United States
Studies in Canada
Other studies Outpatient visits
Children
Adults

Summary Daily mortality
Miscellaneous health effects
Athletic performance, school absenteeism and restricted activity or performance Miscellaneous biological effects Summary
Effects of long-term exposure
Studies of the University of California at
Los Angeles
Seventh-day Adventist studies
Cross-sectional studies
Summary
Summary and concluding remarks References
Health risk evaluation and recommended guideline values for ozone
Summary and health risk evaluation Metabolism Animal studies Controlled human studies Epidemiologic studies Cancer
Recommended guideline values Short-term exposure Long-term exposure